Per- and polyfluoroalkyl substances (PFAS) are a group of thousands of human-made chemicals that have been used in a wide variety of products, including non-stick cookware, stain-resistant fabrics, and firefighting foam. PFAS are very persistent in the environment and can build up in the body over time, hence their other known name, forever chemicals.

Here are some of the potential health effects of PFAS on the microbiome:

Disruption of the gut microbiota balance.

Microbiota disruption. PFAS can disrupt the balance of bacteria in the gut, leading to an overgrowth of harmful bacteria. This can lead to a number of health problems, including inflammation, digestive problems, and obesity.

Alteration of the metabolism of the gut microbiota.

Metabolism alteration. PFAS can alter the metabolism of the gut microbiota, which can lead to changes in the production of short-chain fatty acids. Short-chain fatty acids are important for a number of functions, including gut health, immune function, and energy metabolism.

Increased risk of obesity and insulin resistance. Studies have shown that exposure to PFAS can be associated with an increased risk of obesity and insulin resistance. This may be due to the changes in the gut microbiota that are caused by PFAS exposure.

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