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Up until recently, it was believed that aging was just the natural way of things. That as time passed, our bodies aged, degraded, often became more susceptible to sickness, and eventually would give out and we would cease to be any longer.
Modern medicine, nutraceuticals, and science are amazing and stranger than fiction these days.
As cells get age, they start to lose their ability to process and take in nutritional fuel needed to sustain. This is a major issue that researchers are working on to address in order to improve energy in aging cells.
The fuel supply chain within a cell is important for many reasons, one of which is the production of Nicotinamide Adenine Dinucleotide, or NAD+. Studies have shown that the levels of this chemical in tissues decrease with age. One way that cells can make this chemical is by using a precursor molecule known as Nicotinamide Mono Nucleotide, or NMN, which is found in foods such as avocados, broccoli, and green vegetables. However, exactly how this chemical penetrates these cells has always been a mystery.
A new study conducted by researchers led by Shin-ichiro Imata, PhD, revealed that a protein known as NMN is responsible for moving the non-nuclear material (NMN) into cells. This protein can then be used to produce cellular fuel.
“What may be important in a future strategy is the combination of giving NMN along with stimulating the transport of NMN into cells,” Imai said. “With aging, we see a bottleneck in NAD production. The body loses its ability to manufacture NAD over time. At the same time, it seems to begin burning more NAD, likely due to chronic inflammation. If we can give NMN and aid its transport into cells, that may be a way to bypass the bottleneck.”
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