"As we sit inside our cozy homes, in front of the fireplace that brings us warmth and energy, we feel the benefits and all seems well. What happens if smoke from the fire started billowing out into the room? We are immediately alerted, smoke alarms go off, we are moved to immediate action. We realize that besides providing energy, fires can be dangerous.

Fire produces smoke, free radicals, carbon monoxide, sparks and ash, fires can get out of control. In order to harness the ample benefits of fire, we have made special places in our homes where the fires can be controlled. We have devices that control the fire, harvest the energy, and alert us if the smoke builds up."

"This scenario provides us a great analogy of what is happening inside our trillions of cells. Inside every one of our cells, fuels are delivered, like oils and gasoline (fatty acids and sugars), that burn with the provided oxygen inside an average of 200 controlled furnaces (called mitochondria) in every cell, this fire produces smoke (ROS) that is eliminated by scrubbers (antioxidants) and detected by smoke detectors (thioredoxin semaphores, Nf-kappaB). All of these devices must be in place inside our cells to harness the energy of these metabolic fires."

"The “smoke” that comes out of these cellular fires, reactive oxygen species (ROS), composed mostly of superoxide free radicals (O2*-) and hydrogen peroxide (H2O2), increases when the fires of life flare up inside the mitochondrial furnaces."

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