The art-historical importance of the Palazzo Farnese in Caprarola, near Viterbo, is the famous pentagonal ground plan and round interior courtyard, and the interior frescoes. The Palazzo was built for Cardinal Alessandro Farnese (1520-1589) who was made cardinal by his grandfather Pope Paul III (1468-1549) and named vice-chancellor of the Holy Roman Church a year later, according to him the highest position after that of the pope in the ecclesiastical hierarchy. The architect of the construction of the palace was Giacomo da Vignola.

The Sala del Mappamondo on the piano nobile was painted by Giovanni de' Vecchi, assisted by Raffaellino da Reggio. The decoration of this room consists of monumental maps of the entire known world as well as the depiction of the forty-eight Ptolemaic constellations. The program was completed with portraits of the great discoverers Marco Polo, Christopher Columbus,

Ferdinand Magellan, and Hernando Cortés above the doors and windows of the room; personifications of the depicted countries and parts of the earth; and in a frieze, depictions of the celestial legends with which the ancients had explained the creation of the twelve signs of the zodiac.

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