Colostrum also plays a role in rotavirus and Salmonella Typhi infection protection as well as antibiotic related diarrhea due to presence of
lactoferrin. Studies have shown that hyper immune bovine colostrum, derived from cows immunized with rotavirus, can prevent rotavirus diarrhea when
given passively. Hyper immune colostrum containing different levels of rotavirus antibody was GODHIA & PATEL, Curr Res Nutr Food Sci. Jour., Vol. 1(1), 37-47 (2013) administered to 105 children attending nine Adelaide childcare centers. Subjects were asked to drink 100 ml of whole milk supplemented with colostrum 3 times a day, for a period of 6 days. Stool samples were collected from the subjects before, during and after consumption of the study product.Rotavirus antibody activity was detected in 521 (86%) of 602 fecal specimens obtained during the study using the virus reduction ELISA. The antibody activity was detected as early as 8 hours after ingestion of hyper immune colostrum and up to 72 hours after consumption had ceased. There was a strong relation between the titer of rotavirus antibody administered to subjects and the level of antibody activity detected in the feces.The results show that antirotavirus activity survived passage through the gut. Therefore, passive immunotherapy may be used to prevent or treat infectious diseases that affect the entire length of the gastrointestinal tract. 

Eighteen adults 20-25 years with Salmonella Typhi infections were given 100ml/ prepacked bovine colostrum and group 2 were given false colostrum. It was seen that bovine colostrum neutralizes the infective agent and toxins. Its effect was seen when colostrum immunoglobins modified the interaction of adhesion of pathogens to their target tissues. Thereafte, decreasing the effect of pathogens on the gastrointestinal tract.33It was seen that colostrum has lethal effect on E Histolytica and it protects against diarrhea.Administration at the start of antibiotic treatment reduces the attack rate of diarrhea because colostrum contains lactoferrin which has antimicrobial and anti-inflammatory effect.

CONCLUSION

The nutritional composition of colostrum favors its use as Ancient Food for Modern Times and hence can be considered as a nutraceutical.
Colostrum as reviewed can be of use in variety of setting –athletic performance, maintenance of integrity of mucosa, permeability, local immunity,
systemic immunity and antigen handling. Colostrum supplements can play an important role in autoimmune disorders like rheumatoid arthritis. As
immune modulator as well as have scope in maintenances of growth in children due to presence of growth factors.