If people really want to lose weight, they need to rely on more than their brain. For example, late at night the brain says not to snack but the sweet tooth says just the opposite. Who wins? No contest.

But late night food snackers who want to  stop their bad habits may now have help from leptin-enriched colostrum. Leptin, known as the fat-burning hormone, is intimately tied into the body’s ability to resist sweet treats, by turning on and off particular genetic characteristics that allow the tongue to taste sugar.

The tongue was found to be one of the peripheral targets for leptin. Research on the body’s obesity (ob) gene and leptin thus far have assumed that the protein acts by causing a hormonal response in the brain, leading one to feel satiated. Purdue University Professor Ki- Han Kim, however, has discovered these findings are only partly correct. He says the body’s sense of sweetness declines with leptin deficit, and production in fat cells
slows. The finding gives scientists the first indication that leptin suppresses biochemical reactions in fat cells without the participation of the brain.

When researchers injected laboratory mice with leptin, previously obese mice became as thin as rodent track stars. “It’s true that the animal isn’t eating as much when it is given leptin,” Kim says. “But that doesn’t mean that the brain is initiating this. Whenever we eat, we alter the hormonal status of the body. The body has to tell its various parts to do something with this food that has been ingested. When leptin inhibits fat synthesis, it causes the body to have extra food in its system, which triggers the hormonal system to send a message to the brain saying that the body is satiated and to stop eating.

So leptin’s interaction in the brain isn’t the whole story. Leptin also appears to act via pathways that are independent of the brain. My thinking is that it
works by inhibiting the synthesis of fat in fat cells and increasing the burning of fat in muscle cells. It works at an enzymatic, cellular level.” Kim found that the ob gene causes the muscle cells to produce leptin and suppresses another gene that produces an enzyme essential for fat production known as acetyl-CoA caboxylase (ACC).

To capture the power of leptin, colostrum is one of nature’s richest sources, note researchers from the University of Milan reporting in Hormone and Metabolic Research. They studied leptin content in bovine colostrum and concluded that, “leptin is present in large quantities in colostrum…” Colostrum also contains Insulinlike Growth Factor-1, which is required to metabolize fat for energy, thus supporting the effect of leptin’s impact on caloric control. The effect of colostrum is to increase lean muscle mass and decrease body fat simultaneously. As researcher Dr. Anthony Kleinsmith, PhD, whose
firm Anovite has developed leptin-enriched colostrum supplements, notes, “The benefit is cumulative since increased muscle mass results in more calorie burning and conversion of fat to energy.

Colostrum works while you dream. To experience truly great results, an inch loss program needs to work with your body 24 hours a day seven days
a week, even while you sleep. That’s why Anovite has developed the NightTime formula. Leptin- and collagen-based formulas work with your body’s natural sleep processes to enhance inch loss all night long. The LeptiTrim NightTime formula capitalizes on keeping the thermogenic burn going throughout the night.”

RASPBERRIES HOT WEIGHT LOSS

Leptin-enriched colostrum formulas use weight-loss support nutrients, citrus extracts, raspberry ketones and green tea, a combination with some scientific evidence for appetite inhibition and weight loss. Raspberry ketones, an aromatic component, cause fat breakdown. In one experiment, to test the effect on obesity, mice were fed a high-fat diet plus raspberry ketone for about 10 weeks. Researchers observed that, compared to controls, raspberry ketone decreased the amount of fat in the liver and visceral adipose (abdominal fat) tissues of mice. It also significantly increased norepinephrine-induced lipolysis (the decomposition of fat) in some rat fat cells. Researchers also tested fat cells with raspberry ketone and found
that they showed greater evidence of breakdown when compared to controls. Be forewarned, however; a nutritional supplement is required
consume enough of the raspberry ketones since the equivalent would be eating 90 pounds of the fruit each day.

The Journal of Medicine notes that Citrus aurantium is another natural excellent weight-loss herb, working as a beta agonist. The researchers reported increased metabolic rates and significant weight loss when ingesting Citrus aurantium products. At present, Citrus aurantium may be the best
thermogenic substitute for ephedra. However, more studies are needed to establish this. In another randomized, placebo controlled, double-blind study,

70 obese but otherwise healthy subjects were assigned to receive citrus extracts, raspberry ketones and green tea or a placebo and underwent eight
weeks of daily supplementation, calorie-restricted diet and exercise training. Of the 45 subjects who completed the study, significant differences were observed in body weight, fat mass, lean mass, waist girth, hip girth and energy levels as well as serum leptin.

Collagen is another nighttime weight loss ingredient that can help. Next to water, collagen protein is the most important structural substance in the body, accounting for 25-30% of its total protein. Ligaments, tendons, bones and skeletal muscles are all held together by collagen, as well as
smooth muscle tissue, blood vessels, the digestive tract and many organs. It is even the main component of hair, skin and nails. Collagen protein contains a unique combination and ratio of nonessential, high-nitrogen amino acids, most importantly, glycine, proline, hydroxyproline, and arginine.

These have been shown to influence weight loss; bone and connective tissue; improvement of skin appearance; optimal body growth and repair;
metabolism; and elevation of growth hormone secretion (which also affects fat loss, muscle retention, energy levels, softness and elasticity of the
skin, especially for wounds and improved sleep and healing.).

As for weight loss, collagen itself does not burn fat; however, it places the body’s metabolism in an optimal state to do so. As people age, their bodies tend to lose their muscle tissue and gain more fat. This is why older people are not as toned and firm, even though they may weigh the same as when they were younger. This also affects metabolism, since muscle helps regulate the burning of calories, and thus, fat. Less muscle tissue means a slower metabolism. Greater muscle tissue results in a better metabolism that is able to burn calories and fat. Collagen’s specific high-nitrogen amino acids help to preserve and build lean muscle. By doing so, collagen protein promotes the body’s burning of fat as energy. Also, this is why collagen can be
very effective when taken at bedtime, since during the first stage of sleep the body is in a natural state of repair, building and healing muscle tissue.
This process involves the breaking down of muscle tissue. Using collagen protein at bedtime helps to prevent the breaking down of the body’s muscle, thus increased muscle mass. This is why users typically notice a reduction of fat in inches (not muscle or water weight as with other products) and a firmer, toned body—before the loss of pounds shows on the bathroom scale.