Ehrlicher and colleagues “stressed” the mitochondria of transgenic mice by making the animals exercise on a treadmill. Genetic alterations impaired their exercise-induced autophagy pathway.

The rodents were euthanized 36 hours after their last bout of exercise and 4 hours after their last meal, and the researchers examined the mitochondria in the rodents’ muscle cells.

What the team found was that despite the genetic modification and the added stress of exercise, the mitochondrial function of the mice’s muscles remained intact.

As a next step, Ehrlicher and colleagues fed the mice a high fat diet in addition to the exercise regimen to stress the mitochondria even more.

Again, the mice’s mitochondria showed signs of intact health and adaptation, even with the autophagy pathway blocked. This, explains the study’s lead author, suggests that the mitochondria have alternative ways to stimulate recycling and limit the damage.

Matt Robinson, a researcher in the same department as Ehrlicher and the last and corresponding author of the study, reports on the results.

He says, “[When] these animals were given a high fat diet, they got better at burning off those fats. If they were given just the exercise, they were able to make more mitochondria, which is good from an exercise perspective. And those adaptations seem to be very specific.”

The authors add that the findings elucidate more about how mitochondria work and what keeps them healthy.

The study “helps lay some future groundwork for how we can optimize (muscle and mitochondrial) health to promote their health with diseases like obesity, diabetes, even some implications with aging — conditions that we know have compromised mitochondria,” says Robinson.

Exercise may be one such way of optimizing mitochondrial and metabolic health. “Even without changes in weight, exercise has this amazing ability to improve metabolic health,” Ehrlicher says.

Obese mice do not seem to have an obvious pathway dysfunction in their mitochondria, and the muscles just seem to respond and adapt well to new stress, whether that is exercise or a high fat diet.

This suggests that humans with obesity may potentially benefit from exercise, similarly. In the future, the scientists hope to use human participants to replicate their findings.

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