Non-steroidal anti-inflammatory drugs (NSAIDs) are most commonly prescribed medicine worldwide.Administration of NSAIDs causes gastric
and intestinal damage like peptic ulceration and injury to small and large intestine. It causes increased permeability with protein and blood loss
also stricture formation.  Approximately 2% of subjects taking NSAIDs over a year suffer from adverse gut adverse effect including bleeding, perforation and inflammation. Acid suppressants and prostaglandin analogues have been shown to be effective in reducing gastric injury induced by NSAIDs but are less effective in preventing small intestinal injury.

Therefore novel therapies are required for treatment. Growth factors like α IGF 1, β IGF 1, transforming growth factor (TGF) and epidermal
growth factors (EGF) are present in human and bovine colostrum. These growth factors are capable of stimulating gut growth and repair process of GI
tract. A study was conducted to determine what effect dietary supplementation might have on NSAID induced GI inflammation and permeability (if any).
Bovine Colostrum utilized in the two trials contained approximately 43 g/L protein content (primarily consisting of Immunoglobulin) and the following
growth factor profile (values are approximations): IGF-I and II 2 mg/L, TGF-â 25 g/L, and EGF 6 g/L. The preliminary results obtained suggest benefits
for persons acutely exposed to NSAIDs; however, BC did not appear to provide any GI benefits among persons chronically utilizing NSAIDs. 17
A study with seven males, following an initial baseline permeability assessment, supplemented their diets with 125 mL BC or whey placebo three times daily for seven days. Indomethacin was introduced on days 3-7. After completing this arm of the trial, a two-week washout period was followed by a second arm of the trial in which participants receiving the active intervention were switched to the placebo, while those receiving the placebo received active treatment. Permeability increased approximately three- fold in response to indomethacin in the participants taking the whey placebo while no
significant increase in intestinal permeability was observed when the BC preparation was co administered with indomethacin.In other study 15 persons taking NSAIDs (ibuprofen, piroxicam, voltarol, or naproxen) for at least one year were randomized to receive either 125 mL bovine colostrum or placebo three times daily for seven days with a two-week washout period between study arms. Baseline permeability assessments were lower in these persons than in volunteers in the previous trial (who were not taking NSAIDs chronically). No significant effect of either the active or placebo treatment was observed 

Currently there are few studies that support this observation as the clinical trial are still been carried out in patients with long term use of NSAIDs. In short-term doses of NSAIDs appear to consistently increase intestinal permeability; it is possible that long-term use of NSAIDs results in an
adaptation response by the small intestine, at least in certain individuals. Irrespective of the explanation, bovine colostrum appear to hold
promise as a dietary addition in persons be- ginning NSAIDs, but not for persons chronically taking NSAIDs while being free of adverse GI effects. A
daily dose of 15grams of bovine colostrum may be beneficial in NSAIDs induced gut dysfunction.

It was seen that 15grams of bovine colostrum containing protein content of approximately 43%, helps to prevent NSAIDS induced GI dysfunction