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The Science & Theories Behind Aging and Anti-Aging

Posted by Bobby Brown on October 06, 2020 - 7:18pm Edited 10/6 at 7:19pm


 

Both men and women are constantly searching for ways to both look & feel younger and be healthier. In 2016, for the first time in half a century, US life expediencies dropped for the second year in a row. That same year, the anti-aging market grew to $250 billion dollars, with Americans spending more on anti-aging products than on any other type of drug. Of course, most of these products proved to be ineffective.

A Perspective for Men, Women & Athletes

Aging is characterized by the accumulation of cellular damage, in turn, leading to increased susceptibility to chronic diseases. These diseases each have their root in the aging process itself, since aging is known to be the single highest risk factor for their development. Thus, it becomes crucial to understand aging mechanisms. The process of aging involves different interdependent hallmarks on the cellular, molecular and organ level. One major contributor is the development of cellular senescence, which is the condition or process of deterioration with age including your cell's loss of the power necessary to divide and grow.

So far, there is no single theory that fully explains all facets of aging. The damage accumulation theory is one of the most accepted theories due to the large body of evidence found over the years. Damage accumulation is thought to be driven, among others, by oxidative stress. This condition results in an excess attack of oxidants on biomolecules, which lead to damage accumulation over time and contribute to the functional involution of cells, tissues and organisms. If oxidative stress persists, cellular senescence is a likely outcome and an important hallmark of aging.

So the best theory on aging and disease is that all our health problems are due to cells that are unable to maintain a healthy REDOX potential. The immediate result could be cellular death, overwhelming infection. In our industrialized world our challenges result in chronic imbalances in cellular health causing chronic oxidative stress that the body is unable to overcome. Aging, poor diet, mental stress, poor hydration, and inadequate exercise set the stage for this imbalance, which advances the pace of aging (as well as illness).

The Breakthrough Continues

There's no question that men and women age differently. Obviously, genetics, lifestyle, nutrition, and environment affect how people of either gender age, but the rate and way that men and women age is completely different. Not only do the male and female body respond differently to aging, but the male and female psychology also differs as well. Taken together, aging for men and women can be an entirely different experience, especially different is some of the diseases they face and their exercise and health needs.

 

Ladies First

For women the leading cause of death is heart disease, followed by breast cancer. Most medical conditions and ailments that women face can be controlled and sometimes treated, so there is a possibility of reducing the number of deaths attributed to these illnesses. As research has shown, a healthy diet, exercise and regular medical checkups are the key ingredients for healthy aging for women.

Men, it's Your Turn

There are a number of medical conditions that men commonly suffer as they age. These include BPH, colorectal, prostate cancer and aging male syndrome — which is caused by a decline in testosterone and may manifest in a variety of symptoms including weight gain, difficulty sleeping, less interest in sex, irritability, erectile dysfunction, problems concentrating, increased urination, depression, and loss of bone, muscle and hair. 

The Importance of Glutathione As We Age

Glutathione is the mother of all antioxidants. A molecule our bodies produce naturally to cleanse free radicals and toxins from our system. It is the disease buster and master detoxifier responsible for recycling and recharging EVERY ANTIOXIDANT in our body.

As we age our glutathione levels fall. This makes our bodies extremely susceptible to breakdown and disease. In fact the average 45-year-old has already experienced a 50% decrease in glutathione.

 

ASEA Redox Supplement Impact on Aging

Oxidative damage has been implicated in aging and age-dependent diseases, including cardiovascular disease, cancer, neurodegenerative disorders, and other chronic conditions. If the generation of free radicals exceeds the protective effects of antioxidants and some co-factors, this can cause oxidative damage.

Glutathione peroxidase (GPx) is an essential enzyme in cellular antioxidant defense systems, detoxifying peroxides and hydroperoxides. Superoxide dismutase (SOD) is an enzyme that helps break down potentially harmful oxygen molecules in cells, which might prevent damage to tissues.

In this study, scientists attempted to determine if direct contact of ASEA Redox Supplement to cells affects the antioxidant efficacy of GPx and SOD.

Study Protocol
Cultures of standard epidermal cells were exposed to various small concentrations of ASEA Redox Supplement (less than 1%) and a phosphate buffered saline (PBS) solution for 24 hours. The decrease of oxidants due to GPx enzymatic activity was monitored over an eleven-minute period after a chemical agent (cumene hydroperoxide) initiated the reaction. The reduction of oxidants is an indication of antioxidant efficacy. Three replications of oxidant residual in the samples were read every two minutes to determine GPx efficacy at various concentrations of PBS or ASEA Redox Supplement.

Results Summary
An 800% increase in GPx antioxidant efficacy was seen after 24 hours of exposure from low concentration ASEA Redox Supplement. A transitory increase of up to 500% was observed in SOD antioxidant efficacy between 30 and 90 minutes after exposure to low-concentration ASEA Redox Supplement (< 1%).

Exposure to high concentration ASEA Redox Supplement, in comparison, elicited only a small relative increase in GPx antioxidant efficacy that was not concentration dependent. An increase in SOD efficacy was not seen for either high concentration ASEA Redox Supplement or after long exposures (24 hours).