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Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo. F-4

Effects of resveratrol on LNCaP cell-derived tumor growth in athymic nude mice.

LNCaP cell tumor xenografts were established in athymic nude mice (n = 22 per diet group) as described in Materials and Methods. Tumor volumes were measured twice a week and calculated as described in Materials and Methods. The linear coefficients and standard errors from the random effects model are shown in the graph.

(A) Body weights of control, RES50 and RES100 groups during the study.

(B) Temporal effects on tumor growth in animals fed control (filled circles), RES50 (open circles) or RES100 (filled triangles) diets.

(C) Comparison of tumor volumes between animals fed control, RES50 or RES100 diet in week 3. Week 3 results from Panel B were regraphed, and *indicates significantly different from control at P < 0.05.

(D) Comparison of tumor volumes between animals fed control, RES50 or RES100 diets in week 4. Week 4 results from Panel B were regraphed, and *indicates significantly different from control at P < 0.05.

Article Produced By

Diet, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agriculture Research Service, United States Department of Agriculture, 10300 Baltimore Avenue, Building 307C, Room 132, Beltsville, MD. Laboratory of Cellular Regulation and Carcinogenesis, National Cancer Institutes, National Institutes of Health, Department of Nutrition and Food Science, University of Maryland, College Park, Department of Pharmaceutical Sciences and Pharmacology and Toxicology Graduate Program College of Pharmacy, Washington State University, Pullman, National Food Research Institute, Tsukuba, Ibaraki 305-8642, Japan. Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Biometrical Consulting Service, Beltsville Area, Agriculture Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA. Division of Nutritional Sciences, University of Texas at Austin, Austin, TX 78712, USA. Department of Carcinogenesis, MD Anderson Cancer Center, Smithville, TX 78957, USA
 

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