x
It has been reported that resveratrol may increase expression and serine phosphorylation levels of the tumor suppressor protein p53, thereby affecting activation of p53-dependent signaling pathways, such as inhibition of cell cycle progression and induction of apoptosis. Resveratrol has also been found to decrease expression of prostate-specific antigen (PSA), an androgen-responsive gene (ARG) that is often used as a marker for prostate cancer cell growth.
Moreover, a recent microarray study revealed that resveratrol may exert global effects on ARG expression in LNCaP cells. ARGs such as PSA play important roles in cellular functions, including cell cycle regulation, transcription, cell proliferation and differentiation, as well as metabolism. We have shown previously that estrogen as well as androgen can regulate ARG expression, suggesting that the effects of resveratrol on ARGs may be through modulation of steroid hormone-mediated pathways.
Given the roles of androgen and estrogen in prostate cancer development, modulation of these pathways may contribute to resveratrol’s protective effects against prostate cancer. However, despite the in vitro work suggesting that resveratrol shows promise as a prostate cancer chemopreventive agent, the in vivo effects of resveratrol, as well as the mechanisms underlying those effects on prostate cancer, remain largely unknown.
The present study uses complementary LNCaP cell culture and xenograft models to test the hypothesis that resveratrol is protective against prostate cancer. We also test the hypothesis that resveratrol exerts its effects, in part, through modulation of steroid hormone-dependent pathways. We report here that resveratrol in vitro appeared to affect multiple pathways that impact prostate cancer cell growth, and that the effects of resveratrol are mediated in part by modulation of androgen receptor (AR)- and estrogen receptor-dependent signaling pathways. In vivo, resveratrol initially delayed tumor growth but was also found to decrease tumor apoptosis and increase tumor angiogenesis.
Article Produced By
Posted by
Chuck Reynolds
The reasoning for this article is to supply you information about this wonderful product and also for me to find at least two or more people for this simply Amazing Opportunity.. You just need to follow the 4 simple steps.. (Join,Train,sigup 2 or more people and then you duplicate. It's that simple..). This business can make you money in the thousands or just be a customer for a very satisfying experience.
View this video as it helps you to understand a very simple Business Plan. Check it out, then
View these videos (4 of them, very short (total less then 5 min)) that explains how simple
this business works and if so inclined, click on my name above, call me or just sign up
either as a Customer or Distributor.
