x
Nitric oxide (NO) derived from the endothelial NO synthase (eNOS)
has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.
Article Produced By
Department of Pharmacology, Johannes Gutenberg University Medical Center,
https://www.ncbi.nlm.nih.gov/pubmed/25302702
Red wine polyphenols (RWPs) have been reported to prevent hypertension and endothelial dysfunction. Several individual RWPs exert estrogenic effects. We analyzed the possible in vivo protective effects on blood pressure and endothelial function of RWPs in female spontaneously hypertensive rats (SHR) and its relationship with ovarian function. RWPs (40 mg/kg by gavage) were orally administered for 5 weeks. Ovariectomized rats showed both increased isoprostaglandin F(2alpha) excretion and aortic superoxide production and reduced relaxant response to acetylcholine and contraction to the endothelial nitric oxide synthase (eNOS) inhibitor l-NAME measured in the aorta but similar blood pressure, as compared with sham-operated rats.
Moreover, in ovariectomized rats aortic eNOS expression was unchanged, whereas caveolin-1, angiotensin II receptor (AT)-1, and the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits p22(phox) and p47(phox) expression was increased compared with sham-operated rats. In both ovariectomized and sham-operated SHR, RWPs reduced systolic blood pressure, urinary isoprostaglandin F(2alpha) excretion, and aortic O(2)(-) production, improving the endothelium-dependent relaxant response to acetylcholine in SHR. These changes were associated with unchanged aortic eNOS expression, whereas caveolin-1 was increased and the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits p22(phox) and p47(phox) expression was reduced. RWPs had no effect on the AT-1 overexpression found in ovariectomized animals. All these results suggest that a chronic treatment with RWPs reduces hypertension and vascular dysfunction through reduction in vascular oxidative stress in female SHR in a manner independent of the ovarian function.
Article Produced By
Department of Pharmacology, School of Pharmacy, University of Granada
https://www.ncbi.nlm.nih.gov/pubmed/25302702
Read next article at: https://markethive.com/group/ama/blog/a-study-on-the-effect-of-resveratrol-on-lipid-metabolism-in-hyperlipidemic-mice
Read previous article at: https://markethive.com/group/ama/blog/resveratrol-and-cardiovascular-diseases
Posted by
Chuck Reynolds
The reasoning for this article is to supply information about this wonderful product and also for me to find at least two or more people for this simply amazing opportunity.. You just need to follow the 4 simple steps.. (Join,Train,sigup 2 or more people and then you duplicate. It's that simple..) and it can make you money in the thousands with this business or just be a customer for a very satisfying experience.
There is a video (4 of them, very short (total less then 5 min)) that explains how simple this business works. Check them out then if so inclined, click on my name above and sign up either as a Customer or Distributor.
Thank You
Chuck
chuck@dreams-inn.com
