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Resveratrol, a phytoalexin antioxidant found in red grapes, has been shown to have both chemopreventive and therapeutic effects against many diseases and disorders, including those of the skin. Studies have shown protective effects of resveratrol against ultraviolet radiation mediated oxidative stress and cutaneous damages including skin cancer. Because many of the skin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears to have promise and prospects against a wide range of cutaneous disorders including skin aging and skin cancers. However, there are a few roadblocks in the way of this promising agent regarding its translation from the bench to the bedside. This review discusses the promise and prospects of resveratrol in the management of skin disorders and the associated challenges.
The skin is the body’s largest organ, and is its foremost line of defense against disease. Because of this importance, anything that compromises the skin’s integrity can be detrimental to the overall health of the individual. Also, since the skin is so easily seen by others, even non-life-threatening disorders can cause significant social problems, which can be almost as devastating to those affected with the disease. Most skin disorders and diseases have a complex set of processes responsible for their inception, which can be genetic and/or environmental, and the importance of each factor is different for every disease. However, exposure to solar ultraviolet (UV) radiation is a very important factor in the pathogenesis of many skin disorders, including aging and cancer. UV light can directly cause DNA damage, as well as start a cascade of oxidative stress and related signaling leading to mutation and irreparable damages to the cells. For this reason, it is important to develop novel approaches aimed at fighting the stresses and insults that skin comes into contact with every day, as well as managing the cutaneous disorders that are developed.
Resveratrol, a trihydroxy derivative of stilbene (3,5,4’-trihydroxystilbene) is a naturally occurring phytoalexin antioxidant present in grapes, berries, peanuts and red wine. Trans-resveratrol is found in many plants, and is produced as a form of defense against harmful environmental stimuli, such as a fungus or infection. The earliest work on resveratrol was done examining its effects on cardiovascular health and heart disease. Researchers noticed that the people in France had a much lower incidence of coronary heart diseases than populations in other countries, despite their high saturated fat intake. This was attributed to an increased red wine intake by the French population and was termed the “French Paradox” by Renaud and Lorgeril in 1992. Although earlier work was done examining the effects of resveratrol on cardiovascular disease, much of the recent research done with this antioxidant has been in the areas of cancer chemoprevention and treatment, inflammation, and oxidative stress.
Article Produced By
Department of Dermatology, University of Wisconsin, University of Wisconsin Carbone Cancer Center, Corresponding author: Nihal Ahmad, Medical Sciences Center,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060966/
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