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As discussed prior, some useful research with promising outcomes have been done regarding the effectiveness of resveratrol in photoprotection and against skin cancer. Based on these studies, it appears that the prospects are very bright for the possible use of resveratrol in skin diseases such as UV light mediated skin aging, skin cancer and other inflammatory and hyper-proliferative disorders. Based on studies in skin as well as other model systems, it appears that resveratrol may have prospects against pre-cancerous conditions such as actinic keratosis, as well as in enhancing the therapeutic ability of other drugs that are currently being used to treat skin disorders.
For example, melanoma is one of the most drug-resistant cancers and the standard treatment options used for metastatic melanoma are interferon and dacarbazine, which have not shown a good therapeutic outcome. Some recent pre-clinical studies have suggested that polyphenols in combination with standard treatment options may be a viable approach for melanoma. Further, Yang and colleagues demonstrated that resveratrol is an APE/Ref-1 inhibitor and enhances the therapeutic efficacy of dacarbazine for melanoma. Thus, it appears that resveratrol may have bright prospects as an adjuvant therapy for melanoma management.
Another direction for researchers is to create resveratrol analogs with high efficacy against skin conditions. For example, Wong et al synthesized 4'-ester analogs of resveratrol via decarbonylative Heck coupling to assemble the protected stilbene core structure. These analogs were then tested against melanoma cells. It was found that four of the synthesized compounds are more effective in killing the melanoma cells than resveratrol, and that two out of four compounds had no cytotoxic effects on normal human dermal fibroblasts. Similarly, Moran and colleagues showed that fluorinated analogues of resveratrol had better growth inhibitory potential against melanoma cells. Choi and colleagues synthesized an analogue of resveratrol, 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol (5HNB), which has a potent tyrosinase inhibitory activity. This analogue did not show any cytotoxic effects on B16 melanoma; however, it was found to suppress melanin production by at least 50%.The authors suggested that 5HNB might have skin-whitening effects as well as therapeutic potential for treating skin pigmentation disorders.
Article Produced By
Department of Dermatology, University of Wisconsin, University of Wisconsin Carbone Cancer Center, Corresponding author: Nihal Ahmad, Medical Sciences Center,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060966/
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