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Currently, several topical formulations of resveratrol are being developed. Hung and colleagues have studied several different solutions and hydrogel patches as delivery routes for resveratrol. Hydrogel patches were successfully used in an effort to ensure that the resveratrol stayed at the site of interest, instead of diffusing into the body. Already, a number of resveratrol supplemented skin care products and cosmetics are available in the market. However, these products have not been rigorously tested for their claims.
One problem with the resveratrol formulation used in cosmetics is that in order to allow resveratrol to incorporate into the creams or oils, usually microparticles are used that supposedly prolong its release into the skin. The drawback of this approach is that it also reduces the amount of resveratrol available for penetration into the skin. Recently, Kobierski and colleagues have tried using several different stabilizers and surfactants to produce a stable nanosuspension of resveratrol, and found that two of the non-ionic stabilizers they tested worked very well. The nano-formulations can possibly improve resveratrol transport across the membrane as well as increase solubility. These nanosuspensions were also found to be stable at room temperature for at least 30 days.
As mentioned above, the use of resveratrol via systemic means is marred by its poor bioavailability due to its rapid metabolism in mammals. Therefore, efforts are needed to enhance its bioavailability in humans. We have earlier stressed on certain specific directions to combat this issue. The possible scenarios for aggressive future research in this direction include, i) the strategy of combining resveratrol with agents that can inhibit the in vivo metabolism of resveratrol; ii) use of nanoparticlemediated delivery; iii) synthesis and/or evaluation analogues of resveratrol with improved bioavailability; and iv) careful evaluation of conjugated metabolites of resveratrol which may be deconjugated at the target organ to elicit a biological response.
Resveratrol is a promising antioxidant that is currently being investigated for a variety of disease conditions. It is not a surprise that resveratrol is also being evaluated for the management of skin disorders such as skin aging and skin cancers. Skin is particularly well suited for the use of this promising agent because the antioxidant properties of resveratrol work well against the high oxidative stress that skin cells come under frequently. Resveratrol has shown promise against skin diseases and even more prospects are yet to be explored. Indeed, concerted and multidisciplinary efforts are needed to take-up the challenges which hinder the prospects of this promising agent, in order to take it to the next level i.e. from ‘bench-to-bedside’.
Article Produced By
Department of Dermatology, University of Wisconsin, University of Wisconsin Carbone Cancer Center, Corresponding author: Nihal Ahmad, Medical Sciences Center,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060966/
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