Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials.       

BACKGROUND & AIMS:

The results of human clinical trials that have investigated the effects of resveratrol on blood pressure are inconsistent. We aimed to quantitatively evaluate the effects of resveratrol on systolic blood pressure (SBP) and diastolic blood pressure (DBP).

METHODS:

We conducted a strategic literature search of PubMed, EMBASE, MEDLINE, and the Cochrane Library (updated to January, 2014) for randomized controlled trials that evaluate the effects of resveratrol on SBP and DBP. Study quality was assessed using the Jadad scale. Weighted mean differences were calculated for net changes in SBP and DBP using fixed-effects or random-effects models. We performed pre-specified subgroup, sensitivity and meta-regression analyses to evaluate potential the heterogeneity. Dose effects of resveratrol on SBP and DBP were estimated using meta-regression analyses.

RESULTS:

Six studies comprising a total of 247 subjects were included in our meta-analysis. The overall outcome of the meta-analysis indicates that resveratrol consumption can not significantly reduce SBP and DBP. Subgroup analyses indicated that higher-dose of resveratrol consumption (≥ 150 mg/d) significantly reduces SBP of -11.90 mmHg (95% CI: -20.99, -2.81 mmHg, P = 0.01), whereas lower dose of resveratrol did not show a significant lowering effect on SBP. The meta-regression analyses did not indicate dose effects of resveratrol on SBP or DBP.

CONCLUSIONS:

The present meta-analysis indicates that resveratrol consumption significantly decreases the SBP level at the higher dose, while resveratrol has no significant effects on DBP levels. Additional high-quality studies are needed to further evaluate the causal conclusions.

Article Produced By
The Second Cadres Ward, General Hospital of Shenyang Military Area Command, Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Area Command.

https://www.ncbi.nlm.nih.gov/pubmed/28086917

Read next article at: https://markethive.com/group/ama/blog/multiplicity-of-effects-and-health-benefits-of-resveratrol

Read previous article at: https://markethive.com/group/ama/blog/resveratrol-regulates-neuroinflammation-and-induces-adaptive-immunity-in-alzheimers-disease

Posted by
Chuck Reynolds

The reasoning for this article is in part to bring awareness of the Amazing qualities of what Amazingrape can do for you. It is a very helpful supplemental product. It can help you and others as well. You can make alot of money with this business or just be a customer for a very satisfying experience.

There is a video (4 of them, very short (total less then 5 min)) that explains how simple this business works. Check them out then if so inclined, click on my name above and sign up either as a Customer or Distributor.

Thank You
Chuck