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There’s some reason to believe that resveratrol can give you just that–not just a longer lifespan, but a longer healthspan. More time spent as an active, young to middle-aged adult, and more time overall, without spending more time in the nursing home. In studies, resveratrol has been shown to greatly extend the lifespans of yeast, worms and flies, as well as protecting against age-related diseases like cancer and Alzheimer’s in mammals.
Maybe you’ve read articles about how resveratrol might be the reason why wine is good for you (it isn’t), or maybe you’ve just heard about it from some wine snob who used it to explain why drinking an entire bottle of 2009 douchenozzle reserve every evening is, like, tooootally healthy. Regardless, it’s something you should know about. Resveratrol has fallen somewhat off the radar since it was all the rage a few years ago. but the research on it keeps piling up. Short answer: Yes, resveratrol may very well help you live longer and stay younger. The long answer is a bit more complicated.
We’ll start with the basics. Resveratrol is a phenol–a sort of naturally occurring compound–produced by certain plants as an immune response against stress and fungal infections. It’s produced by a variety of berries, as well as peanuts and cocoa plants, but the highest concentrations are found in the skins of red grapes, as well as in dry red wines. It naturally occurs in two forms, called trans-resveratrol and cis-resveratrol. These forms are isomers–mirror images of each other, sort of like your left and right hands. Trans-resveratrol is the one that purportedly confers health benefits, and a glass of red wine will typically have anywhere between .15 and 1.5 mg of it.
Resveratrol appears to exert most of its effects by inducing cell apoptosis and autophagy, a pair of mechanisms by which the body kills off and recycles old, damaged or non-functioning cells, organelles, protein and bits of RNA. In effect, it works by some of the same mechanisms as caloric restriction and fasting, but without requiring you to do either of those things. For a while in the 2000’s, it really looked like resveratrol was some kind of miracle drug. Every year, a few more studies would come out demonstrating benefits to longevity, cardiovascular fitness, and brain health. But then three things happened that changed the narrative.
First, more research started coming out on autophagy, and as it turns out, autophagy isn’t always good for you. Specifically, while autophagy can extend your lifespan and prevent cancer, autophagy within cancer cells can help them survive the onslaught of both the body’s natural immune response and medical cancer treatments. So the benefits of resveratrol could be a double-edged sword, although autophagy is certainly helpful far more often than it’s harmful.
Second, a 2011 meta-analysis concluded that while resveratrol had proven highly beneficial in animals, there was insufficient justification for recommending it for human use at that time. The study did however say that resveratrol seemed promising, suggested several avenues for further research, and concluded that the scientific community should definitely be spending a lot more money on resveratrol research.
You may have noticed that I didn’t link to that study. Well hold onto your dicks, because shit’s about to get cray. In 2012 an investigation found that Dr. Dipak Das, a cardiovascular researcher and author of dozens of resveratrol studies, had been falsifying lab tests and misrepresenting the data in almost every study he was involved in since at least 2005. You heard that right: many of the great things you’ve heard about resveratrol are based on fake studies.
Funny enough, he was also a co-author in the 2011 meta-analysis which had suggested spending more money on resveratrol research. Who’d have guessed? Following this revelation, most of the most positive studies on resveratrol had to be retracted, as did that meta-analysis. Then in 2013, Dr. Das died of undisclosed causes– I’m going to go ahead and guess heart disease. Since then, more (apparently legit) research has been done on resveratrol by other (apparently honest) scientists. So what’s the deal? Is resveratrol bullshit? No. Is it a miracle drug? No. Is it worth looking at? Hell yes it is, so let’s go over its purported benefits one by one.
Article Produced By
John Fawkes
Hardcore evidence-based fitness and self-improvement
(All these Articles can be read starting with this URL: https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5 )
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