What Is New for an Old Molecule?
Systematic Review and Recommendations on the Use of Resveratrol P-1

Introduction

Resveratrol (Resv) is a simple molecule that has taken the spotlight since the first scientific paper described a possible preventive effect on cancer in mice. Resveratrol occurs naturally in low amounts in various edible plants, but the fact that Resv is found in red wine increases its relevance as being easily accessible to the general population. The applications of Resv therefore receive strong attention from the general population, the scientific community and companies invested in food additives, cosmetics and “natural medicine.”

A number of long-term clinical studies in humans have recently been initiated or is under planning and ideally in 2–5 years, we will know much more about the biological effects of Resv in humans. But before these data are available, the prediction of biological effects of Resv in humans have to rely primarily on data obtained in experimental animals and from in vitro screening in combination with elucidation of its mechanism of action. All reliable Resv data should be included to convert knowledge generated in animals into a clinically safe Resv treatment approach in humans. Therefore, a critical evaluation of the present scientific state-of-the-art knowledge is needed.

The aim of the recent conference, Resveratrol2010, 1^st International Conference on Resveratrol and Health was to present the state-of-art of knowledge in the Resv field. After the conference invited speakers and the scientific committee formed a working group which formulated the recommendations described herein.

The task of the working group discussion was to formulate a number of scientifically based recommendations for ¹the human use of resveratrol and ²research on resveratrol for the coming years based on scientific literature and data made available during the previous 2½ days of the conference. As Resv has been suggested to promote health in relation to various diseases or sufferings, the participating scientists covered a broad range of research on the biological effects of Resv, which included the following subjects, ¹resveratrol and cancer; ²resveratrol and heart disease; ³neuroprotective activity of resveratrol; ⁴effect of resveratrol on longevity; ⁵effect of resveratrol on inflammation; ⁶effect of resveratrol on obesity and diabetes; ⁷metabolism and stability of resveratrol and ⁸production and commercial use of resveratrol.

Methods

To generate a scientifically valid foundation for the formulation of these recommendations, a systematic search was performed in MEDLINE (http://www.ncbi.nlm.nih.gov/pubmed/) and ISI Web of Science (http://apps.isiknowledge.com/) to indentify studies in humans or experimental animals on Resv in relation to cancer, coronary heart disease, diabetes/metabolic syndrome, neurodegenerative diseases and inflammation up to September 2010. The search terms “resveratrol” was used in combination with “cancer”, “carcinogenesis”, “chemoprevention”, “hypertension”, “heart failure”, “myocardial infarct”, “cardiac arrest”, “ischemia heart disease”, “stroke”, “serum lipids”, “metabolic syndrome”, “obesity”, “diabetes”, “insulin sensitivity”, “plasma glucose”, “visceral fat”, “neuroprotection”, “neuroprotective”, “inflammation” or “inflammatory”, were used to search for words in titles, abstracts, or Medical Subject Headings. The search was limited to English language but include both human data and experimental animals. Beside the database searches a manual search was performed using reference lists of original articles and previous reviews. For all studies, only the original publication was included in the present evaluation. Only studies investigating Resv and Resv metabolites are evaluated whereas various derivatives of resveratrol were not included.

The identified publications were used to answer the following five questions: ¹Can resveratrol be recommended in the prevention or treatment of human diseases?; ²Are there observed side effects caused by intake of resveratrol in humans?; ³What is the relevant dose of resveratrol?; ⁴What valid data are available regarding an effect in various species of experimental animals?; ⁵Which relevant (overall) mechanisms of action of resveratrol have been documented?

Article Produced By

Department of Science, System and Models, Roskilde University, Department of Science, System and Models, Roskilde University, Department of Dermatology, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Animal and Dairy Science, University of Georgia, Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Department of Cancer Studies and Molecular Medicine, The Biocentre, University of Leicester, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut, United States of America, INSERM U866, University of Burgundy, Department of Biochemistry, Postgraduate Programme of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Signal Transduction Laboratory, Ordway Research Institute, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Laboratory of Physiological Studies, Section on Oxidative Stress Tissue Injury, National Institutes of Health, Department of Biochemistry and Biotechnology, Annamalai University, College of Pharmacy, University of Hawaii at Hilo,¹⁵ UFR Pharmacie, University of Bordeaux, Proteomics Laboratory, Indian Institute of Toxicology Research, College of Pharmacy, Seoul National University, Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Department of Biochemistry and Molecular Biology, New York Medical College,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116821/

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