Leptin is another hormone that plays an important role in obesity.

It is produced by fat cells and its blood levels increase with higher fat mass. For this reason, leptin levels are especially high in people with obesity.

In healthy people, high leptin levels are linked to reduced appetite. When working properly, it should tell your brain how high your fat stores are.

The problem is that leptin isn’t working as it should in many obese people, because for some reason it cannot cross the blood-brain barrier

This condition is called leptin resistance and is believed to be a leading factor in the pathogenesis of obesity.

SUMMARYLeptin, an appetite-reducing hormone, doesn’t work in many obese individuals.