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Growing Evidence Links Resveratrol to Extended Life Span P12

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Bioavailability

Laboratory and animal studies clearly show that resveratrol and its derivatives are biologically active. However, Dr. Zhao-Wilson notes that there are “significant issues related to what is currently known about resveratrol’s bioavailability—it appears to be rapidly metabolized in humans.” Dr. Sovak agrees, commenting, “One problem with resveratrol is that we do not know that much about its resorption and bioavailability in humans, but as expected, the compound is rapidly metabolized and excreted.”

Scientists are exploring ways to optimize resveratrol’s pharmacokinetics. For example, in the Czech Republic, where resveratrol has been approved as a nutritional supplement, Dr. Sovak and his colleagues conducted a pilot study in humans comparing high-purity, pharmaceutical-grade resveratrol to resveratrol glycon, the natural form of resveratrol extracted from the Polygonum plant. Of the two preparations, resveratrol glycon was found to be more easily absorbed in the body and to have better pharmacokinetics.

Another method under investigation to improve resveratrol’s bioavailability is administering it concomitantly with plant-derived flavonoids. Numerous studies suggest that the bioflavonoid quercetin slows the inactivation of resveratrol, thus improving its bioavailability. A novel type of quercetin, quercetin chalcone, demonstrates superior absorption and solubility, and may thus be the optimal form of this bioflavonoid.

Article Produced By
Life Extension

https://www.lifeextension.com/magazine/2007/3/report_resveratrol/Page-03

(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5 

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