x
In addition to exploring resveratrol’s many potential health applications, researchers are also trying to determine the optimal dose needed to capture its benefits. “There have been insufficient studies to date in humans to address issues related to optimal dose,” notes Dr. Zhao-Wilson. “Extrapolation of optimal dose from animal studies to humans is always more of an art than a science, and the appropriate studies still need to be done. Nevertheless, reasonable assumptions can be made, and there is even evidence that low doses may be effective for certain conditions.”
Many commercially available supplements provide 20 mg of resveratrol daily. The rationale behind this dosage is that prior to the widespread use of pesticides, French red wine contained approximately 20 mg of resveratrol per liter, and those drinking about a liter daily appeared to derive the cardioprotective benefit associated with the French paradox. Now that the resveratrol content in red wine has decreased to 90 micrograms per fluid ounce,50 a 20-mg (20,000-mcg) resveratrol supplement contains approximately 220 times the amount of resveratrol in one fluid ounce of red wine, or about 41 times the amount in one glass of red wine.
Studies by BioMarker have shown that resveratrol offers benefits for gene expression and longevity in a variety of species using a dosage comparable to 20 mg daily in humans. However, given the extraordinary findings of recent studies using high-dose resveratrol supplements—and their profound implications for human health—some resveratrol researchers and other health-conscious people are now consuming even larger daily dosages.
As for who should supplement with resveratrol, leading researchers maintain that in addition to benefiting patients with specific disease conditions, resveratrol may confer broad-spectrum protection to anyone seeking to live a long life in optimal health. According to Dr. Zhao-Wilson, “the properties associated with resveratrol appear to be largely protective—cardioprotective, neuroprotective, anticarcinogenic, anti-inflammatory—and the current data suggest that most people could benefit from dietary supplementation with resveratrol obtained from a high-quality source.” Dr. Zhao-Wilson adds that resveratrol is generally safe when taken in conventional dosages.
Dr. Sovak similarly recommends resveratrol as a health-protective agent, noting that resveratrol may be helpful both alone and in combination with other antioxidants, such as epigallocatechins derived from green tea.51,52 Turn to the next article for more precise information about optimal resveratrol dosing.
Article Produced By
Life Extension
https://www.lifeextension.com/magazine/2007/3/report_resveratrol/Page-03
(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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