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Resveratrol protects a cell's DNA. It is a powerful antioxidant. Antioxidants can help prevent cell damage caused by free radicals. Free radicals are unstable atoms caused by pollution, sunlight and our bodies natural burning of fat that can lead to cancer, aging and brain degeneration.
Resveratrol has been promoted to have many health benefits such as protecting the heart and circulatory system, lowering cholesterol, and protecting against clots which can cause heart attacks and stroke. Animal studies have suggested it can lower blood sugar levels. Because resveratrol is considered an antioxidant, it is often promoted to reduce the incidence of various cancers. Animal studies also suggest resveratrol may lower brain plaque levels in Alzheimer’s disease. However, well-controlled, human clinical trials are lacking in all of these areas and many of the resveratrol claims are based in animal studies in mice. Resveratrol is considered a dietary supplement and is not approved by the U.S. Food and Drug Administration for any indication. Definitive studies demonstrating appropriate doses, uses, long-term safety and effectiveness have not been conducted.
However, the clinical utility of resveratrol in humans is under investigation. Animal studies in mice suggest there might be benefits of weight loss, reduction in insulin resistance, and reducing mortality in diabetes. Anti-cancer effects have been demonstrated in animals models, as well. Human research with resveratrol is limited. A small and brief randomized, double-blind, cross-over study in the November 2011 issue of Cell Metabolism demonstrated that 150 mg of resveratrol once daily for 30 days significantly lowered mean systolic and arterial blood pressure, tumor necrosis factor (a marker of inflammation), plasma glucose and insulin concentrations, and plasma triglyceride concentrations, among other findings. Adverse reactions to resveratrol were not seen in the study. Researchers note that longer studies at higher doses are required before results can be confirmed.
Article Produced By
L. Anderson, PharmD - Senior Editorial Pharmacist - BS, PharmD, with specialized residency in Drug Information.
Sanjai Sinha, MD - Medical Doctor - Internal Medicine - Albert Einstein College of Medicine of Yeshiva University, 1998.
Kaci Durbin, MD - Medical Doctor. /-Sophia Entringer, PharmD - PharmD, BCPS.
J. Stewart, BPharm - Senior Editorial Pharmacist/Information Systems Pharmacist.
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