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According to the bibliography, we could state that resveratrol has many beneficial properties. Its small molecular structure and polyphenolic character endow resveratrol with antioxidant properties and the ability to bind to organic compounds present in many organisms, such as hormone receptors and enzymes. This ability to interact with biological molecules provides resveratrol with multiple biological activities that are evident and clear when studied in vitro. These include beneficial effects against tumor processes, cardiovascular parameters, and longevity. However, some discrepancies have been observed in in vivo studies.
The concentrations used in vitro are too high to be reached in the organism after red wine consumption. However, it is possible to achieve such high concentration of resveratrol in plasma by administering resveratrol supplements and that is how many of the in vitro results have been verified in animal tests. However, if nutrients containing resveratrol are used to test these effects in vitro, the results show little biological activity. This is due to the small amount of resveratrol present in natural products and its low bioavailability limits its activity in the target tissues. The issue of bioavailability is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol. In fact, free resveratrol can even bind to plasma proteins that could serve as a reservoir.
Clarifying aspects like stability and pharmacokinetics of resveratrol metabolites would be fundamental to understand and apply the therapeutic properties of resveratrol. Further research into resveratrol uptake, cellular destination, metabolism, and stability of the original molecule and that of its metabolites is needed to elucidate its biological activity and it would be crucial to take advantage of the efficiency of its properties.
Read next article at: https://markethive.com/group/ama/blog/resveratrol-how-much-wine-do-you-have-to-drink-to-stay-healthywine-as-a-biological-fluid-history-production-and-role-in-disease-prevention
Read previous article at: https://markethive.com/group/ama/blog/properties-of-resveratrol-in-vitro-and-in-vivo-studies-about-metabolism-bioavailability-and-biological-effects-in-animal-models-and-humans-p4
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Chuck Reynolds
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Thank You
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