x
Resveratrol:
Aside from drug metabolizing enzymes, it is now greatly acknowledged that transport function modifications are involved in these resveratrol-drug interactions. Resveratrol has been reported to potently inhibit P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), and organic anion transporter 1/3 (OAT1/OAT3). Nonetheless, resveratrol interactions with transporters are still not fully elucidated. Furthermore, few clinical studies were conducted to determine transporter-mediated resveratrol-drug interaction. On the other hand, it is also speculated that higher resveratrol doses compete with other polyphenols for transporters, reducing both their uptake and potential synergistic effects. Moreover, absorption, distribution, renal excretion, and/or hepatic elimination of resveratrol active ingredients in humans is not well-explored than required for actual resveratrol-drug interactions prediction. Thus, resveratrol modulating effects on transporter-drug interactions warrants further investigation.
Resveratrol has been reported to hinder human platelet aggregation in vitro. Presumably, high resveratrol intakes in the form of supplements could enhance both bruising and bleeding risk when taken with anticoagulant drugs, antiplatelet drugs and even non-steroidal anti-inflammatory drugs (NSAIDs).
Article Produced By
Biomedicines
Author Info
1Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran;
2Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran
3Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
4Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
5Gazi University Faculty of Pharmacy Department of Pharmacognosy, Ankara 06330, Turkey; (B.S.);(M.K.)
6Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
7Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box. 812, Yaounde-Cameroon.
8Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
9Institute for Research and Innovation in Health (i3S), University of Porto, Porto 4200-135, Portugal
10Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
11Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/
(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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