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Resveratrol protective effect was shown to improve cardiovascular function in diabetic rats by preserving the functional abilities of cardiac stem/progenitor cell compartments and mature cardiac cells, improved cardiac environment by reducing inflammatory state and decreased unfavorable ventricular remodeling of the diabetic heart, leading to a marked recovery of ventricular function. Resveratrol showed beneficial effect in heart failure by improving left ventricle function, decreased cardiac hypertrophy, contractile dysfunction and remodeling, interstitial fibrosis, and the level of plasma BNP.
Some molecular mechanism of resveratrol action include inhibition of prohypertrophic signaling molecules, improvement of myocardial Ca2+ handling, phosphorylation of prosurvival (Akt-1, GSK-3β) and stress signaling (MKP-1) pathways and the reduction of oxidative stress and inflammation (iNOS, COX-2 activity, and ROS formation). Yan et al. suggest that resveratrol act by preventing the expressions of endothelial nitric oxide synthase, vascular endothelial growth factor, and suppressing phosphorylation of p38 in rats with diabetes-related myocardial infarction. Besides, resveratrol administration in myocardial infarction-related diabetic rats significantly reduced blood glucose, body weight, plasma triglyceride levels, heart rate and aspartate transaminase (AST)/alanine transaminase (ALT) ratio, at same time that markedly increased total plasma insulin levels.
In addition, resveratrol significantly reduced inflammation factors and malondialdehyde levels, which is a marker of oxidative stress. These results showed that resveratrol treatment can improve cardiovascular function by reducing myocardial ischemia-reperfusion injury, vasodilation and atherosclerosis. Contrarily, at physiological concentrations, resveratrol induces vasodilation, and consequently decreases hypertension and cardiovascular diseases risk. On the other hand, these results have also confirmed the uses of Polygonum cuspidatum as a resveratrol source to treat and to prevent hyperlipidemia and arteriosclerosis in traditional chinese medicine. Overall, the cardiovascular protective effect of resveratrol have been linked to multiple molecular targets and might be useful to the development of novel therapy for atherosclerosis, metabolic syndrome, ischemia/reperfusion, and heart failure.
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Biomedicines
Author Info
1Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran;
2Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran
3Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
4Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
5Gazi University Faculty of Pharmacy Department of Pharmacognosy, Ankara 06330, Turkey; (B.S.);(M.K.)
6Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
7Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box. 812, Yaounde-Cameroon.
8Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
9Institute for Research and Innovation in Health (i3S), University of Porto, Porto 4200-135, Portugal
10Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
11Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/
(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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