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Stilbenoids including resveratrol are non-nitrogenous polyphenols with acidic and amphiphilic characters with anti-inflammatory activity. Many of their targets are occurring on cyclooxygenase (COX), 5-lipoxygenase (5-LOX) and protein kinase B, which is associated with its ability to inhibit COX-1 and COX-2 activity along with transcription factors activity inhibition, directly involved in COX activity regulation. Studies reported the ability of resveratrol to reduce the secretion and expression of inflammatory factors.
The anti-inflammatory activity of resveratrol prevents acute pharyngitis-induced inflammation by inhibiting NF-κB, tumor necrosis factor-α and interleukin-6 serum levels, macrophage inflammatory protein-2 and cyclooxygenase-2 activity levels, reactive oxygen species production and caspase-3/9 in rabbit models. Resveratrol inhibit the ear oedema of mice, WBC and pleurisy exudates, decrease the production of NO, and elevate the activity of SOD in serum in acetic acid-induced pleurisy test, reduce the content of MDA and elevate the T-SOD activity in serum; RSV could inhibit the expressions of TP, PGE2, NO, and MDA in carrageenan-induced synovitis test supporting its analgesic and anti-inflammatory activities.
Resveratrol inhibit the activation of microglia that lead to the release of various pro-inflammatory factors, the production of reactive oxygen species, and the activation of signal pathways leading to neuroinflammation in in vitro resveratrol modulates the inflammatory response at moderate to high concentrations within intestinal cells by down-regulating NF-κB activation and preventing mitochondrial dysfunction. This result was confirmed in vivo where resveratrol inhibits TNF-α production and NF-κB activation, decreases neutrophil infiltration in the intestinal mucosa, and represses intestinal tumorigenesis by regulating anti-inflammatory miRNA. Chen et al. demonstrated that resveratrol significantly suppressed the TLR-4/MyD88/NF-κB signaling pathway in lysophosphatidylcholine-induced damage and inflammation that might be useful for treatment of arteriosclerosis. Taken together, these studies suggest that resveratrol can prevent inflammation and oxidative stress, reduce the risk of carcinogenesis and developed as anti-inflammatory agent to improve the quality of life of patients.
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Biomedicines
Author Info
1Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran;
2Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran
3Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
4Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
5Gazi University Faculty of Pharmacy Department of Pharmacognosy, Ankara 06330, Turkey; (B.S.);(M.K.)
6Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
7Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box. 812, Yaounde-Cameroon.
8Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
9Institute for Research and Innovation in Health (i3S), University of Porto, Porto 4200-135, Portugal
10Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
11Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/
(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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