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Besides the cardioprotective, antioxidant, anticancer, neuroprotective, anti-inflammatory, anti-dyslipidemia, and antidiabetic effects of resveratrol, it also exhibits antiproliferative and androgen-lowering effects on theca-interstitial cells of ovary. Moreover, it exerts a cytostatic but not cytotoxic effect in granulosa cells, while inhibiting aromatization and vascular endothelial growth factor (VEGF) expression. These actions may be of clinical relevance in conditions associated with theca-interstitial cell hyperplasia, androgen excess, and abnormal angiogenesis, such as polycystic ovary syndrome. In addition, resveratrol may increase ovarian follicular reserve and prolong ovarian life span, serving as a potential anti-aging agent.
Resveratrol is also able to decrease histopathological and biochemical damages and to exert protective effects on ischemia-reperfusion injury induced ovarian damages. Resveratrol has become to continue a hotspot in many fields, including respiratory system diseases. Indeed, research has demonstrated that resveratrol is helpful in relieving pulmonary function in general population and plays a protective role in respiratory system diseases. The main protective effects of resveratrol in respiratory system diseases, including its anti-inflammatory, antiapoptotic, antioxidant, antifibrotic, antihypertensive, and anticancer activities were also examined. In resveratrol-treated patients, serum levels of certain biochemical markers (i.e., C-reactive protein, erythrocyte sedimentation rate, undercarboxylated osteocalcin, matrix metalloproteinase-3, tumor necrosis factor alpha, and interleukin-6) were also significantly decreased.
Therefore, the use of resveratrol as an adjuvant to conventional antirheumatic agents seems to be an optimum approach. Resveratrol can also be used as a protective and/or therapeutic agent, particularly in male infertility cases caused by testicular toxicity. On the other hand, resveratrol could be useful to protect health against several pathologies and ageing problems. However, the comparative evaluation of animal and human studies shows that resveratrol cannot protect against metabolic diseases and their relevant complications. Nonetheless, it is important to point out that the clinical findings are influenced by many factors, such as sample size and study objectives. Till now, small sample size and high dosage levels were used to conduct most of clinical trials to assess resveratrol significance in chronic diseases. Consequently, it is not easy to determine the exact safety range and therapeutic effectiveness of specific resveratrol doses on specific populations. In this sense, before prescribing resveratrol, patients should be properly advised for effective treatment with minimum side effects. Further evaluations are needed before declaring resveratrol as a beneficial compound for human health.
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Biomedicines
Author Info
1Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran;
2Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran
3Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
4Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
5Gazi University Faculty of Pharmacy Department of Pharmacognosy, Ankara 06330, Turkey; (B.S.);(M.K.)
6Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
7Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box. 812, Yaounde-Cameroon.
8Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
9Institute for Research and Innovation in Health (i3S), University of Porto, Porto 4200-135, Portugal
10Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
11Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/
(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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