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In a very interesting study, dose-time dependency of acute resveratrol administration on lipoperoxidation levels (in heart, liver and kidney of male rats synchronized with a 12-h dark-light cycle) was investigated. It was documented that resveratrol behaved as an antioxidant during dark span and as a pro-oxidant during light span, possibly reflecting the putative changing ratio between pro- and antioxidant activities in various organs during 24-h cycle or postprandial oxidative burst that occurred after a meal. There is an interesting correlation among dietary polyphenols pro-oxidant and cytotoxic activities, such as to resveratrol. In fact, since every antioxidant is a redox agent it might become a pro-oxidant, accelerating lipid peroxidation and/or inducing DNA damages under special conditions. In this way, it has been proposed that such pro-oxidant action could be an important mechanism of action to resveratrol anti-cancer and apoptotic-inducing properties.
It has already been reported that resveratrol can lead to DNA damages, as well as to a reversible or irreversible cell cycle interruption mediated by its pro-oxidant effect. Recently, Plauth et al. proposed that cellular response to resveratrol treatment is based on oxidative triggering action, that can lead to cell fitness hormetic induction towards a more reductive state, so as to physiological resilience raising in fight oxidative stress. Also, it has been reported earlier that a critical balance between intracellular hydrogen peroxide (H2O2) and O2– decides cells fate to apoptotic stimuli. Thus, a shift towards H2O2 favors apoptosis, whereas inclination towards O2- obstructs apoptosis. Indeed, H2O2 promotes apoptosis by reducing intracellular O2- concentration and triggering cytosolic pH drop. Ahmad et al. reported that resveratrol inhibitory effect on H2O2-induced apoptosis is not due to its antioxidant activity, but rather, through a pro-oxidant effect evidenced by the prominent raise in intracellular O2- production, which creates a non-conducive intracellular environment for apoptotic execution.
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Biomedicines
Author Info
1Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran;
2Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran
3Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
4Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal 246174, Uttarakhand, India;
5Gazi University Faculty of Pharmacy Department of Pharmacognosy, Ankara 06330, Turkey; (B.S.);(M.K.)
6Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran
7Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci, P.O. Box. 812, Yaounde-Cameroon.
8Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal
9Institute for Research and Innovation in Health (i3S), University of Porto, Porto 4200-135, Portugal
10Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
11Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/
(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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