x
mTOR regulates autophagy through inhibitory phosphorylation of ULK1 and inhibition of mTOR decreases the inhibitory phosphorylation level of ULK1 and increases autophagy. Therefore, to confirm the involvement of mTOR in resveratrol-induced autophagy and to examine the ULK1 dependency, we analyzed the level of autophagy induced by resveratrol in the presence or absence of ULK1. ULK1 knockdown using shRNA abolished resveratrol-induced autophagy, indicating that ULK1 is required for resveratrol-induced autophagy. However, ULK1 knockdown did not abolish autophagy induced by H-89 treatment, again confirming that the mTOR-regulated autophagy is independent of the cAMP-PKA pathway. Together, we concluded that resveratrol induces autophagy through the mTOR-ULK1 pathway, which includes inhibition of mTOR.
Article Produced By
Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 689-798, Republic of Korea
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Republic of Korea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763238/
(All these Articles can be read with this URL:
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5 )
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