x
Resveratrol was reported to directly inhibit various enzymes as demonstrated by in vitro activity assays. Among these enzymes, PI3K and PKC showed ATP-dependent inhibition by resveratrol. However, the studies provided no evidence for the link between the inhibition of these molecules and the beneficial effects of resveratrol administration. Further studies are needed to determine the position of physiological targets of resveratrol. In addition to kinases, PDE, which uses cAMP as a substrate, is also inhibited by resveratrol in a substrate-competitive manner.
Notably, mTOR had the lowest IC50 value for resveratrol compared to PI3K, PKC, and PDE. Resveratrol, ATP, and cAMP are similar in structure, which suggested that resveratrol could compete with cAMP or ATP for single binding sites. Additionally, PP242 and quercetin, an mTOR kinase inhibitor and a natural polyphenol, respectively, are similar in structure.
We found that resveratrol showed a cancer-cell-type-selective effect on viability in that it suppressed only the viability of MC7 cells, but not that of SW620 cells. However, we could not find any differences in the level of apoptosis between MCF7 and SW620 cells, which may indicate the involvement of other cellular processes. Notably, Colin et al. suggested acquired resistance to resveratrol in SW620 cells, which is dependent on the DNA-damage response. Therefore, it remains to be determined whether mTOR and the DNA-damage response are associated with the determination of resveratrol resistance in SW620 cells.
Article Produced By
Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 689-798, Republic of Korea
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Republic of Korea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763238/
(All these Articles can be read with this URL:
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5 )
Posted by
Chuck Reynolds
The reasoning for this article is to supply you information about this wonderful product and also for me to find at least two or more people for this simply Amazing Opportunity.. You just need to follow the 4 simple steps.. (Join,Train,sigup 2 or more people and then you duplicate. It's that simple..). This business can make you money in the thousands or just be a customer for a very satisfying experience.
View this video as it helps you to understand a very simple Business Plan. Check it out, then
View these videos (4 of them, very short (total less then 5 min)) that explains how simple
this business works and if so inclined, click on my name above, call me or just sign up
either as a Customer or Distributor.
