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The beneficial properties of the phenolic compounds present in grapes and wine have been studied after the discovery of the “French Paradox.” This term refers to the fact that in north France there is a high intake of saturated fat but low mortality from coronary heart disease compared to other countries where the same high saturated fat intake exists, being the Paradox attributable to high wine consumption. In fact, there are more and more studies dealing with the ability of grape polyphenols and red wine to protect against different types of diseases. Resveratrol is one of the most studied red wine molecules and, in fact, there are more than 1000 references about its properties in the bibliography. Some of these studies in vivo and in vitro are described in.
Because of its chemical and physical features, resveratrol can either cross passively cell membranes or interact with membrane receptors. Therefore, it may interact with extracellular and intracellular molecules. For this reason, its mechanism of action at the cellular level may be triggered by either activating signaling pathways when binding to cell membrane receptors, activating intracellular mechanisms, or even developing its effects inside the nucleus.
Article Produced By
Neelam Khaper
Academic Editor:
Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Gascó Oliag Street 5, 46010 Valencia, Spain.Sports Research Centre, Miguel Hernández University of Elche, University Avenue, s/n, 03202 Elche, Alicante, Spain.
*J. Gambini: se.vu@inibmag.naujAcademic Editor: Neelam Khaper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499410/
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