Resveratrol: The Anti-Aging Powerhouse That’s Good for the Heart, Brain & Waistline P-9

Resveratrol Benefits
How It Works
Resveratrol works by modifying inflammation in the body, in addition to having other positive effects on hormone production, blood circulation and fat storage. Studies demonstrate that it specifically seems to work in some of the following ways:
- It limits the body’s ability to produce sphingosine kinase and phospholipase D, two molecules known to trigger inflammation. Studies have demonstrated resveratrol’s ability to suppresses the expression and activity of cyclooxygenase enzymes tied to inflammatory responses that damage tissue throughout the body. Although the body naturally produces inflammation as a means of healing and protecting itself, such as to counter bacteria and viruses as part of the immune system, a state of chronic or constant inflammation is not a healthy state to be in. It ages the body and increases risk for almost every disease.
- Resveratrol has been found to lower insulin levels, which is key to staying young, at a healthy weight and fighting diseases like diabetes. In trials, Sirtris Pharmaceuticals found that those with diabetes who took resveratrol had lower glucose and insulin levels, making it a powerful aid to a healthy lifestyle. It also has positive effects on brain-derived neurotrophic factor (BDNF) that’s involved in the pathogenesis of obesity, type 2 diabetes and metabolic syndrome. Researchers have observed that BDNF levels are lower in people with type 2 diabetes mellitus and other insulin-related problems.
- It facilitates mitochondrial respiration and gluconeogenesis. In other words, it helps the “powerhouse” part of cells (the mitochondria) that supplies cells with energy to work optimally.
- Resveratrol keeps circulation flowing smoothly, preventing arterial damage and offering protection in the brain from memory loss and conditions, including Alzheimer’s disease. It may also prevent other disorders, such as stroke, ischemia and Huntington’s disease, in addition to mental health problems like depression, schizophrenia, bipolar disorder and autism.
- It’s been shown to have positive effects on vascular endothelial growth factor — in other words repairing damaged blood vessels.
- Because it controls release of pro-inflammatory molecules, resveratrol thus has benefits for preventing autoimmune diseases. It also seems to positively alter gut microbiota and influences stem cell proliferation and differentiation.
- Finally, as a potent antioxidant, resveratrol is constantly fighting damage from free radicals that can increase cancer risk. It deeply penetrates the nucleus and mitochondria of each cell, helping repair harmful effects due to free radical damage that can alter DNA. It also modulates apoptosis (destruction of harmful cells) and therefore seems to have anti-cancer properties. Studies have found evidence of resveratrol triggering apoptosis of activated T cells and suppressing growth of tumors, in addition to acting against cancer.
Article Produced By
Dr. Josh Axe
Dr. Josh Axe, DC, DNM, CNS, is a doctor of chiropractic, certified doctor of natural medicine and clinical nutritionist with a passion to help people eat healthy and live a healthy lifestyle. In 2008, he started a functional medicine center in Nashville, which grew to become one of the most renowned clinics in the world.
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