Several studies in animals have suggested that resveratrol supplements may change blood fats in a healthy way. A 2016 study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements. Researchers found the average total cholesterol levels and body weight of the mice decreased, and their levels of "good" HDL cholesterol increased.

Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production. As an antioxidant, it also may decrease the oxidation of "bad" LDL cholesterol. LDL oxidation contributes to plaque buildup in artery walls. In one study, participants were given grape extract that had been boosted with extra resveratrol.

After six months of treatment, their LDL had gone down by 4.5% and their oxidized LDL had gone down by 20% compared to participants who took an unenriched grape extract or a placebo.

Summary:
Resveratrol supplements may benefit blood fats in animals. As an antioxidant, they may also decrease LDL cholesterol odixation.

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