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A fluid ounce of red wine averages around 90 micrograms of resveratrol.13 The resveratrol supplements used by Life Extension members contain 20 mg (20,000 mcg) of resveratrol in each capsule. Therefore, these 20-mg resveratrol supplements provide approximately 220 times the amount of resveratrol found in one fluid ounce of red wine. Since a glass of wine is approximately 5 and 1/3 ounces, a person taking one 20-mg resveratrol supplement may ingest the equivalent amount of resveratrol found in 41 glasses of red wine. Needless to say, that is a lot of red wine.
In the studies conducted by BioMarker Pharmaceuticals, mice demonstrated favorable anti-aging gene-expression changes in response to receiving the human equivalent of 20 mg of resveratrol a day. The very positive study results reported in the media in late 2006 used human-equivalent doses of resveratrol in the hundreds or thousands of milligrams a day. So what we have now are extremely favorable data on resveratrol (along with other grape constituents), with a wide range of probable optimal doses for aging humans to consider.
Those who choose to consume 20 mg of resveratrol a day can take comfort in the BioMarker research showing that this potency exerted impressive changes in critically important genes involved in various aging processes and degenerative diseases. Those who choose to consume higher doses of resveratrol can look at the media-reported studies that also showed very impressive results. The good news for consumers is that they can obtain standardized resveratrol and other grape constituents in 20 mg and 100 mg capsules, at a very moderate cost.
Footnotes:
* Doses of drugs in experimental animals are often calculated in milligrams (mg) per kilogram (kg) of body weight. This enables the doses to be standardized among treatment groups.
** A threshold p-value of 0.001 for a minimum two-fold change in level of gene expression was used; this means that the probability that the gene-expression level is statistically significant is 99.9% or more.
Article Produced By
Life Extension
https://www.lifeextension.com/magazine/2007/3/report_resveratrol/Page-04
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https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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