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When we discuss the ability of nutrients like resveratrol, drugs like metformin, and experimental regimens such as caloric restriction to induce favorable changes in gene expression in experimental animals, most people do not realize the ultimate objective of this type of research. While the DNA in the nucleus of our cells includes thousands of genes, it appears that relatively few of these genes control functions that are critical to optimal health and longevity.
As mammals (including humans) age, beneficial genes are “turned down,” whereas genes that are detrimental to cellular function are “turned up.” Some genes may be turned off and on with advancing age, and others may have positive influences in youth, but negative influences as we grow older.
Examples of beneficial genes that are “turned down” during normal aging are genes that:
Examples of detrimental genes that are “turned up” during normal aging include those that:
By causing the genes involved in aging to function as they did in youth, it may become possible in the future to reprogram our genes to keep us alive in a state of perpetual youth, which could lead to biological immortality.
Just consider: although caloric restriction was discovered to extend maximum life span in mammals in the 1930s, only recently have scientists begun to identify the molecular mechanisms that may explain the benefits of caloric restriction, as well as potential caloric-restriction mimetics such as resveratrol and metformin. The implications of these findings—which have made headline news around the world—is that it may someday be possible to engineer our genes in a way that will make us invulnerable to atherosclerosis, cancer, dementias, arthritis, and all other age-related disorders, as well as aging itself. The net effect would be a radical extension of the healthy human life span.
Article Produced By
Life Extension
https://www.lifeextension.com/magazine/2007/3/report_resveratrol/Page-03
(All these Articles can be read from this URL: )
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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