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Resveratrol is similar in structure to estrogen, and thus can activate some of the same receptors that estrogen activates. Higher doses of resveratrol have been found to increase testosterone production in both mouse ovaries and mouse testicles and testicular tumors. Man, imagine being the person who has to study cancerous mouse balls. That’d make for some fun cocktail party conversations.
In humans, higher doses of resveratrol (around 500 mg a day) have been shown to inhibit aromatase. Aromatase is the enzyme that converts testosterone into estrogen, so aromatase inhibition means more testosterone but less estrogen. Really high doses of resveratrol- one gram or more per day- also appear to act as an aromatase inhibitor for one week, but then there’s a rebound effect where high-dose resveratrol increases aromatization after the first week.
Why would it have one effect for one week, and the opposite effect after? There are two possibilities: first off, the high dosage might desensitize your receptors, causing them to eventually stop responding both to resveratrol as well as your body’s natural estrogen. Second, testosterone levels could build up to the point where they overcome the aromatase inhibiting effect, cascading over into estrogen.
Article Produced By
John Fawkes
Hardcore evidence-based fitness and self-improvement
(All these Articles can be read with this URL: https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5 )
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