x
In fact, resveratrol is able to bind to estrogen receptors alpha and beta (ER-α and ER-β) with similar affinities, but this interaction is 7000 times less powerful than that of estradiol. Molecular studies have shown that the union of resveratrol to ER-α is stereoselective, that is, that the trans-isomer shows more affinity for this receptor than the cis-isomer. The chemical structure of resveratrol is similar to that of 17-β-estradiol or synthetic estrogens like diethylstilbestrol. Thus, several studies have been carried out in order to test its ability to act as a phytoestrogen.
Estrogens and phytoestrogens exert almost all of their effects through binding to estrogen receptors. When estrogen binds to its receptor, it activates the transcription of target genes. We found that antioxidant genes were upregulated by this mechanism. Resveratrol can bind to estrogen receptors and activate the transcription of such genes with similar concentrations to those required for its other biological effects. In this regard, Gehm et al. demonstrated in 1997 that resveratrol behaves as an estradiol analog. They used MCF-7 cells, which are rich in estrogenic receptors. Maximal efficiency binding was at 10 μM. This subsequently activated genes with estrogen responsive elements (ERE). Furthermore, to confirm that resveratrol starts ERE activation, they used estrogenic antagonists and the effect was inhibited. By contrast, it has also been shown that resveratrol, in its capacity of an estrogen receptor modulator, can also antagonize the effect of estradiol on increasing proliferation of MCF-7 cells, at higher doses.
Regarding its estrogenic activity, it has been shown that it does not have any effect on the growth and differentiation in the uterus of growing rats. In the same article, the authors did not find any effect of resveratrol on either radial bone growth, serum cholesterol levels, or animal body weight. This study concludes that resveratrol does not act as an agonist in rats at doses from 1 to 100 μg/day. Even with higher doses (1000 μg/day) the effect is insignificant and could also act as an estrogen antagonist.
Article Produced By
Neelam Khaper
Academic Editor:
Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Gascó Oliag Street 5, 46010 Valencia, Spain.Sports Research Centre, Miguel Hernández University of Elche, University Avenue, s/n, 03202 Elche, Alicante, Spain.
*J. Gambini: se.vu@inibmag.naujAcademic Editor: Neelam Khaper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499410/
(All these Articles can be read from this URL:
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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