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Resveratrol can interact with the αVβ3 integrin receptor in MCF-7 cells (a breast-cancer cell line) inducing apoptosis. Besides, it shows antagonist actions when binding to the aryl hydrocarbon receptor, which has immunosuppressive and carcinogenic activity in cells. Nevertheless, these studies conclude that resveratrol inhibits cellular proliferation at concentrations within 10–30 μM. In particular, the effect is locked in phase G/S2 of the cellular cycle, suggesting an inhibition in the enzymatic activities responsible for DNA duplication. These effects have been observed in a cell line of prostate cancer with a concentration of 25 μM but not with 2.5 μM.
Some studies show that it can exert its antitumor effects on the initiation, promotion, and progression of cancer in tumor cells. In this regard, it has been shown how resveratrol at 15 μM is able to inhibit cyclooxigenase 1 (COX-1), a very active enzyme involved in tumor progression. In addition, at 11 μM, it induces phenotypic nonproliferative markers, like the reduction of the nitroblue tetrazolium activity. In the initiation of tumor cells, it acts to inhibit the formation of free radicals at 27 μM on leukemia cells (HL-60). In hepatoma cells (Hepa LcLc7), it inhibits hepatic reductase activity, an enzyme which produces hepatic toxicity, at concentrations of 21 μM. In addition, at 18 μM, the incorporation of thymidine is inhibited, indicating the end of differentiation and thus the transformation to a nonproliferative phenotype. In MCF-7 cells, 10 μM resveratrol blocks the aryl hydrocarbon receptor obtaining beneficial effects against cancer, as it is reported that the activation of this receptor may be involved in some types of tumors. The anticancer effect of resveratrol in MCF-7 has also been associated with BCL-2 and NF-kappaβ. Between 10 and 40 μM, it induces apoptosis via p53 activation in human lymphoblast cell lines. It can also inhibit ribonuclease reductase or COX-2 activity. For that reason, resveratrol has antitumor effects when administered in vitro.
In vivo studies show beneficial effects. For example, its preventive effect on the initiation of cancer has been determined in a skin cancer animal model, with a concentration between 1 and 25 μM of resveratrol, and administrated twice a week. Thus, in vivo studies support the antitumor beneficial effects previously seen in in vitro studies.
Article Produced By
Neelam Khaper
Academic Editor:
Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Gascó Oliag Street 5, 46010 Valencia, Spain.Sports Research Centre, Miguel Hernández University of Elche, University Avenue, s/n, 03202 Elche, Alicante, Spain.
*J. Gambini: se.vu@inibmag.naujAcademic Editor: Neelam Khaper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499410/
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