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Platelet aggregation is inhibited by resveratrol both in vitro and in vivo. There are studies that suggest that resveratrol, at concentrations of 0.1, 1, and 10 μM binds to calcium channels producing 20, 30, and 50% inhibition of thrombin, respectively. This is very beneficial for the cardiovascular system, due to its interference in the formation of blood clots.
Those effects on platelet aggregation showed in in vitro studies mentioned above have also been shown in an in vivo study in rabbits, when a dose of 4 mg/kg/day of resveratrol was administered. Other cardiovascular effects attributed to resveratrol are the regulation of the accumulation of triglycerides and the regulation of the lipolysis in murine adipocytes. When human adipocyte cells (3T3-L1 and SGBS) are incubated with resveratrol at 100 μM, a decrease in triglycerides is observed by an induction of lipolysis, activating adipose triglyceride lipase, and by inducing lipid mobilization. Thus, authors suggest a possible treatment for obesity
Article Produced By
Neelam Khaper
Academic Editor:
Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Gascó Oliag Street 5, 46010 Valencia, Spain.Sports Research Centre, Miguel Hernández University of Elche, University Avenue, s/n, 03202 Elche, Alicante, Spain.
*J. Gambini: se.vu@inibmag.naujAcademic Editor: Neelam Khaper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499410/
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