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It has been reported that resveratrol can extend lifespan in some organisms, such as the budding yeast Saccharomyces cerevisiae, involving a similar mechanism to that of calorie restriction (CR). Further studies have confirmed these results in the Caenorhabditis elegans nematode and the Drosophila melanogaster fly. This effect has been shown to be mediated by the activation of sirtuin 2, an enzyme induced, for example, by calorie restriction, physical exercise, and ethanol consumption.
Sirtuins (Sirt or Sir, from “silent information regulator”) belong to a family of enzymes with deacetylase activity. These enzymes have the ability to modify covalently the histones that cover the DNA by deacetylation, inhibiting the transcription of certain genes. They can also activate or inhibit important enzymes by deacetylation. These enzymes can be activated by resveratrol consumption. Further studies seem to verify this capacity of resveratrol to increase lifespan using Drosophila spp. and C. elegans. In this context, a CR-sirtuin-prolonging lifespan association was established, in which a low-calorie diet would activate sirtuins and regulate mechanisms which extend lifespan. It was suggested that resveratrol could activate the same mechanisms as CR so that the new association was resveratrol-sirtuin-prolonging lifespan.
However, in the past years, the role of Sir2 and resveratrol in aging and the relationship with CR have brought about controversy. In fact, some authors postulate that resveratrol cannot activate Sirt2 in vivo and that CR could increase fly lifespan regardless of Sirt2 activation. Thus, a recent study performed on 30 and 130 μM resveratrol pretreated honey bees showed that resveratrol was able to extend lifespan under normal conditions, but not under hyperoxia.
Article Produced By
Neelam Khaper
Academic Editor:
Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Gascó Oliag Street 5, 46010 Valencia, Spain.Sports Research Centre, Miguel Hernández University of Elche, University Avenue, s/n, 03202 Elche, Alicante, Spain.
*J. Gambini: se.vu@inibmag.naujAcademic Editor: Neelam Khaper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499410/
(All these Articles can be read from this URL:
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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