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In a recent study, which was carried out on five-year-old male grey mouse lemurs (Microcebus murinus), resveratrol decreased glycemia after an oral glucose loading without decreasing fasting blood insulin, mimicking the effects of calorie restriction. In humans, a recent study reported an improvement of insulin sensitivity in plasma glucose in subjects with impaired glucose tolerance, after four weeks of daily resveratrol administration (1 and 2 g/day), showing no differences between doses.
Regarding resveratrol's potential to mimic the beneficial effects of calorie restriction, in a recent human study on obese individuals who were administered 150 mg/day of resveratrol for 30 days, it induced similar metabolic changes as those achieved with CR, such as a reduction in sleeping and resting metabolic rate and an increase of AMPK, Sirt1, PGC-1α, and citrate synthase activity. However, the above mentioned controversy still exists in humans..
Another effect attributed to resveratrol is the protection against the vulnerability associated with frailty. It seems to act as a neuroprotective agent due to its anti-inflammatory activity and its ability to decrease the levels of tumor necrosis factor, cyclooxygenase 2, inducible nitric oxide synthase, and interleukins. Such neuroprotective activity could also be mediated by increasing Sirt1 activity, because this enzyme is thought to increase neurotrophic factors, such as brain-derived neurotrophic factor (BDNF). Specifically, in mice with a phenotype of accelerated aging (SAMP8) an increase of Sir and BDNF is produced when rats are calorie-restricted.
Article Produced By
Neelam Khaper
Academic Editor:
Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Blasco Ibáñez Avenue 15, 46010 Valencia, Spain.Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Gascó Oliag Street 5, 46010 Valencia, Spain.Sports Research Centre, Miguel Hernández University of Elche, University Avenue, s/n, 03202 Elche, Alicante, Spain.
*J. Gambini: se.vu@inibmag.naujAcademic Editor: Neelam Khaper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499410/
(All these Articles can be read from this URL:
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5
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