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Ivermectin, ‘Wonder drug' from Japan: the human use perspective

Posted by Marketing Director on September 19, 2021 - 7:25pm

Facts vs Agendas

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Abstract

Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug.

Introduction

There are few drugs that can seriously lay claim to the title of ‘Wonder drug’, penicillin and aspirin being two that have perhaps had greatest beneficial impact on the health and wellbeing of Mankind. But ivermectin can also be considered alongside those worthy contenders, based on its versatility, safety and the beneficial impact that it has had, and continues to have, worldwide—especially on hundreds of millions of the world’s poorest people. Several extensive reports, including reviews authored by us, have been published detailing the events behind the discovery, development and commercialization of the avermectins and ivermectin (22,23-dihydroavermectin B), as well as the donation of ivermectin and its use in combating Onchocerciasis and lymphatic filariasis.16) However, none have concentrated in detail on the interacting sequence of events involved in the passage of the drug into human use.

When it first appeared in the late-1970s, ivermectin, a derivative of avermectin (Fig. ​(Fig.1 )1 ) was a truly revolutionary drug, unprecedented in many ways. It was the world’s first endectocide, forerunner of a completely new class of antiparasitic agents, potently active against a wide range of internal and external nematodes and arthropods. In the early-1970s, a novel international Public Sector–Private Sector partnership was initiated by one of us (Ōmura, then head of the Antibiotics Research Group at Tokyo’s Kitasato Institute), forming a collaboration with the US-based Merck, Sharp and Dohme (MSD) pharmaceutical company. Under the terms of the research agreement, researchers at the Kitasato Institute isolated organisms from soil samples and carried out preliminary in vitro evaluation of their bioactivity. Promising bioactive samples were then sent to the MSD laboratories for further in vivo testing where a potent and promising novel bioactivity was found, subsequently identified as being caused by a new compound, which was named ‘avermectin’.7) Despite decades of searching around the world, the Japanese microorganism remains the only source of avermectin ever found.1) Originating from a single Japanese soil sample and the outcome of the innovative, international collaborative research partnership to find new antiparasitics, the extremely safe and more effective avermectin derivative, ivermectin, was initially introduced as a commercial product for Animal Health in 1981. It is effective against a wide range of parasites, including gastrointestinal roundworms, lungworms, mites, lice and hornflies.712) Ivermectin is also highly effective against ticks, for example, the ixodid tick Rhipicephalus (Boophilusmicroplus, one of the most important cattle parasites in the tropics and subtropics, which causes enormous economic damage. Indicative of the impact, in Brazil, where some 80% of the bovine herd is infested, losses total about $2 billion annually.13) Today, ivermectin is being used to treat billions of livestock and pets around the world, helping to boost production of food and leather products, as well as keep billions of companion animals, particularly dogs and horses, healthy. The ‘Blockbuster’ drug in the Animal Health sector, meaning that it achieved annual sales in excess of over US$1 billion, maintained that status for over 20 years. It is so useful and adaptable that it is also being used off-label, sometimes, illegally, for example to treat fish lice in the aquaculture industry, where it can have a negative impact on non-target organisms. It also has extensive uses in agriculture.2)

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Figure 1.

Molecular diagrams of avermectin and the di-hydro derivative, ivermectin.

Ivermectin proved to be even more of a ‘Wonder drug’ in human health, improving the nutrition, general health and wellbeing of billions of people worldwide ever since it was first used to treat Onchocerciasis in humans in 1988. It proved ideal in many ways, being highly effective and broad-spectrum, safe, well tolerated and could be easily administered (a single, annual oral dose). It is used to treat a variety of internal nematode infections, including Onchocerciasis, Strongyloidiasis, Ascariasis, cutaneous larva migrans, filariases, Gnathostomiasis and Trichuriasis, as well as for oral treatment of ectoparasitic infections, such as Pediculosis (lice infestation) and scabies (mite infestation).14) Ivermectin is the essential mainstay of two global disease elimination campaigns that should soon rid the world of two of its most disfiguring and devastating diseases, Onchocerciasis and Lymphatic filariasis, which blight the lives of billions of the poor and disadvantaged throughout the tropics. It is likely that, throughout the next decade, well over 200 million people will be taking the drug annually or semi-annually, via innovative globally-coordinated Mass Drug Administration (MDA) programmes. Indeed, the discovery, development and deployment of ivermectin, produced by an unprecedented partnership between the Private Sector pharmaceutical multinational Merck & Co. Inc., and the Public Sector Kitasato Institute in Tokyo, aided by an extraordinary coalition of multidisciplinary international partners and disease-affected communities, has been recognized by many experts and observers as one of the greatest medical accomplishments of the 20th century.15) In referring to the international efforts to tackle Onchocerciasis in which ivermectin is now the sole control tool, the UNESCO World Science Report concluded, “the progress that has been made in combating the disease represents one of the most triumphant public health campaigns ever waged in the developing world”.16)

You can read the rest of the article here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/

Do not let political agendas blind you from the truth.


 

We are Serves of TRUTH - Otherwise, we will autodestroy - Thanks for sharing
September 19, 2021 at 7:55pm
Îs very eficace, whie not îs used...!?
September 19, 2021 at 7:56pm
Thanks for this share, Tom. A whole lot of misinformation and suppression of info has been going on regrading ivermectin. This has to be addressed by all who cares about the people who are and would be affected by Covid.
September 19, 2021 at 8:12pm
Very inexpensive, effective. However, governments worldwide are suppressing distribution, and labeling any talk of it as disinformation. "Vaccines" are where the big money is.
September 20, 2021 at 1:50am
Interesting info , thanks for sharing
September 20, 2021 at 2:15am
Thank you, Tom.
September 20, 2021 at 7:51am
Widely used in South Africa...it really works!!
September 20, 2021 at 10:00am
Thanks for the blog
September 20, 2021 at 11:34am
Thanks for sharing the health benefits of the wonder drug, ivermectin, Tom - great to read the truth.
September 20, 2021 at 11:52am
Spasibo
September 20, 2021 at 12:46pm
Thanks for sharing the truth Tom. This rabbit hole of lies and manipulation is so very deep, but it is good that many more people are now seeing beyond the deception. There are many types of healing modalities that have been kept from the public for many years because of a preference for profit rather than the betterment of mankind. All the Best.
September 20, 2021 at 1:01pm
I have read more times about ivermectin in Czechia but it is approved here only for experimental use. Thanks for the detailed article.
September 20, 2021 at 8:22pm
This is great. Thanks so much.
September 21, 2021 at 6:53pm
I prefer Ivermectin, even if it were only approved for experimental use, like in Czechia, over the "experimental vaccines" that have NOT passed the proper FDA mandates, with regards to the testing procedures set forth in their documentation. Also, he vaccines should have never received emergency use authorization (EUA), since there are plenty of "proven" treatments for the virus. Scientists and doctors have already proven the fact that patients can be cured if administered the proper treatment. However, for some reason, the doctors in the hospitals are scared to death if they do not follow the mandated protocol by the CDC, NIH and Dr. Flip-Flop Fauci. Learn more here: https://www.flemingmethod.com/ and make sure you watch the Event 2021 recording...it will blow your mind.
September 21, 2021 at 11:28pm
Ivermectin is wildly used in South Africa & rest of Africa for many years and very safe if used correctly
Ivermectin proved to be even more of a ‘Wonder drug’ in human health
September 22, 2021 at 3:31am
Thanks Tom for sharing.
September 22, 2021 at 12:20pm
This is such great info. Thanks so much. Shalom!
September 24, 2021 at 11:30pm
Thanks for sharing this great article, Tom. Ivermectin can be picked up over the counter here in Mexico at most drug stores ... over the counter. NO prescription needed. I have a supply just in case.
September 29, 2021 at 1:15pm
Glad you shared this informative information. I will ask at the health food store where I can get some.
October 1, 2021 at 8:38pm
Great information, thanks for the share Tom, here in South Africa it was getting expensive to buy as so many people are using it.
October 5, 2021 at 1:40pm
Thanks for sharing
October 10, 2021 at 3:10am
Awesome! I learnt something new
October 10, 2021 at 8:28am
Thanks for the in-depth article, but more importantly where to buy without being gouged?
October 13, 2021 at 2:33am
local rural veternarians
October 13, 2021 at 2:50am
Thanks for reminder, time to do due diligence
October 13, 2021 at 2:58pm
thanks for sharing
October 20, 2021 at 11:38pm
in Russia, they are vaccinating for free in almost all stores
November 9, 2021 at 2:33am
Thank you
November 14, 2021 at 4:30am
So educating thanks for sharing
November 24, 2021 at 9:29pm
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